diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
index 8db6d6fff0..d366a36e8f 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
@@ -317,10 +317,10 @@ public class AutowiredAnnotationBeanPostProcessor extends InstantiationAwareBean
 		// Fall back to class name as cache key, for backwards compatibility with custom callers.
 		String cacheKey = (StringUtils.hasLength(beanName) ? beanName : clazz.getName());
 		InjectionMetadata metadata = this.injectionMetadataCache.get(cacheKey);
-		if (metadata == null) {
+		if (InjectionMetadata.needsRefresh(metadata, clazz)) {
 			synchronized (this.injectionMetadataCache) {
 				metadata = this.injectionMetadataCache.get(cacheKey);
-				if (metadata == null) {
+				if (InjectionMetadata.needsRefresh(metadata, clazz)) {
 					metadata = buildAutowiringMetadata(clazz);
 					this.injectionMetadataCache.put(cacheKey, metadata);
 				}
diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/InjectionMetadata.java b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/InjectionMetadata.java
index 26a0d0b7f7..636b103764 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/InjectionMetadata.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/InjectionMetadata.java
@@ -90,6 +90,11 @@ public class InjectionMetadata {
 	}
 
 
+	public static boolean needsRefresh(InjectionMetadata metadata, Class<?> clazz) {
+		return (metadata == null || !metadata.targetClass.equals(clazz));
+	}
+
+
 	public static abstract class InjectedElement {
 
 		protected final Member member;
diff --git a/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java b/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java
index 239ac169ad..c973a01b08 100644
--- a/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java
+++ b/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java
@@ -315,10 +315,10 @@ public class CommonAnnotationBeanPostProcessor extends InitDestroyAnnotationBean
 		// Fall back to class name as cache key, for backwards compatibility with custom callers.
 		String cacheKey = (StringUtils.hasLength(beanName) ? beanName : clazz.getName());
 		InjectionMetadata metadata = this.injectionMetadataCache.get(cacheKey);
-		if (metadata == null) {
+		if (InjectionMetadata.needsRefresh(metadata, clazz)) {
 			synchronized (this.injectionMetadataCache) {
 				metadata = this.injectionMetadataCache.get(cacheKey);
-				if (metadata == null) {
+				if (InjectionMetadata.needsRefresh(metadata, clazz)) {
 					LinkedList<InjectionMetadata.InjectedElement> elements = new LinkedList<InjectionMetadata.InjectedElement>();
 					Class<?> targetClass = clazz;
 
diff --git a/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java b/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java
index ef3e4af4d5..51ee76472a 100644
--- a/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java
+++ b/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java
@@ -380,10 +380,10 @@ public class PersistenceAnnotationBeanPostProcessor
 		// Fall back to class name as cache key, for backwards compatibility with custom callers.
 		String cacheKey = (StringUtils.hasLength(beanName) ? beanName : clazz.getName());
 		InjectionMetadata metadata = this.injectionMetadataCache.get(cacheKey);
-		if (metadata == null) {
+		if (InjectionMetadata.needsRefresh(metadata, clazz)) {
 			synchronized (this.injectionMetadataCache) {
 				metadata = this.injectionMetadataCache.get(cacheKey);
-				if (metadata == null) {
+				if (InjectionMetadata.needsRefresh(metadata, clazz)) {
 					LinkedList<InjectionMetadata.InjectedElement> elements = new LinkedList<InjectionMetadata.InjectedElement>();
 					Class<?> targetClass = clazz;