diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
index 1d20cee428..870378487c 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
@@ -233,6 +233,12 @@ public class AutowiredAnnotationBeanPostProcessor extends InstantiationAwareBean
 		metadata.checkConfigMembers(beanDefinition);
 	}
 
+	@Override
+	public void resetBeanDefinition(String beanName) {
+		this.lookupMethodsChecked.remove(beanName);
+		this.injectionMetadataCache.remove(beanName);
+	}
+
 	@Override
 	@Nullable
 	public Constructor<?>[] determineCandidateConstructors(Class<?> beanClass, final String beanName)
diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/support/AbstractAutowireCapableBeanFactory.java b/spring-beans/src/main/java/org/springframework/beans/factory/support/AbstractAutowireCapableBeanFactory.java
index a0d6fa4494..22bfb11772 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/support/AbstractAutowireCapableBeanFactory.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/support/AbstractAutowireCapableBeanFactory.java
@@ -415,8 +415,8 @@ public abstract class AbstractAutowireCapableBeanFactory extends AbstractBeanFac
 			throws BeansException {
 
 		Object result = existingBean;
-		for (BeanPostProcessor beanProcessor : getBeanPostProcessors()) {
-			Object current = beanProcessor.postProcessBeforeInitialization(result, beanName);
+		for (BeanPostProcessor processor : getBeanPostProcessors()) {
+			Object current = processor.postProcessBeforeInitialization(result, beanName);
 			if (current == null) {
 				return result;
 			}
@@ -430,8 +430,8 @@ public abstract class AbstractAutowireCapableBeanFactory extends AbstractBeanFac
 			throws BeansException {
 
 		Object result = existingBean;
-		for (BeanPostProcessor beanProcessor : getBeanPostProcessors()) {
-			Object current = beanProcessor.postProcessAfterInitialization(result, beanName);
+		for (BeanPostProcessor processor : getBeanPostProcessors()) {
+			Object current = processor.postProcessAfterInitialization(result, beanName);
 			if (current == null) {
 				return result;
 			}
diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/support/DefaultListableBeanFactory.java b/spring-beans/src/main/java/org/springframework/beans/factory/support/DefaultListableBeanFactory.java
index ed40ab417f..5e5bf365fe 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/support/DefaultListableBeanFactory.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/support/DefaultListableBeanFactory.java
@@ -65,6 +65,7 @@ import org.springframework.beans.factory.SmartInitializingSingleton;
 import org.springframework.beans.factory.config.AutowireCapableBeanFactory;
 import org.springframework.beans.factory.config.BeanDefinition;
 import org.springframework.beans.factory.config.BeanDefinitionHolder;
+import org.springframework.beans.factory.config.BeanPostProcessor;
 import org.springframework.beans.factory.config.ConfigurableBeanFactory;
 import org.springframework.beans.factory.config.ConfigurableListableBeanFactory;
 import org.springframework.beans.factory.config.DependencyDescriptor;
@@ -969,6 +970,13 @@ public class DefaultListableBeanFactory extends AbstractAutowireCapableBeanFacto
 		// (e.g. the default StaticMessageSource in a StaticApplicationContext).
 		destroySingleton(beanName);
 
+		// Notify all post-processors that the specified bean definition has been reset.
+		for (BeanPostProcessor processor : getBeanPostProcessors()) {
+			if (processor instanceof MergedBeanDefinitionPostProcessor) {
+				((MergedBeanDefinitionPostProcessor) processor).resetBeanDefinition(beanName);
+			}
+		}
+
 		// Reset all bean definitions that have the given bean as parent (recursively).
 		for (String bdName : this.beanDefinitionNames) {
 			if (!beanName.equals(bdName)) {
diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/support/MergedBeanDefinitionPostProcessor.java b/spring-beans/src/main/java/org/springframework/beans/factory/support/MergedBeanDefinitionPostProcessor.java
index 02d050aead..a58b927923 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/support/MergedBeanDefinitionPostProcessor.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/support/MergedBeanDefinitionPostProcessor.java
@@ -1,5 +1,5 @@
 /*
- * Copyright 2002-2016 the original author or authors.
+ * Copyright 2002-2018 the original author or authors.
  *
  * Licensed under the Apache License, Version 2.0 (the "License");
  * you may not use this file except in compliance with the License.
@@ -45,4 +45,13 @@ public interface MergedBeanDefinitionPostProcessor extends BeanPostProcessor {
 	 */
 	void postProcessMergedBeanDefinition(RootBeanDefinition beanDefinition, Class<?> beanType, String beanName);
 
+	/**
+	 * A notification that the bean definition for the specified name has been reset,
+	 * and that this post-processor should clear any metadata for the affected bean.
+	 * @param beanName the name of the bean
+	 * @since 5.1
+	 */
+	default void resetBeanDefinition(String beanName) {
+	}
+
 }
diff --git a/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java b/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java
index c650d460cb..772d5972a1 100644
--- a/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java
+++ b/spring-context/src/main/java/org/springframework/context/annotation/CommonAnnotationBeanPostProcessor.java
@@ -299,6 +299,11 @@ public class CommonAnnotationBeanPostProcessor extends InitDestroyAnnotationBean
 		metadata.checkConfigMembers(beanDefinition);
 	}
 
+	@Override
+	public void resetBeanDefinition(String beanName) {
+		this.injectionMetadataCache.remove(beanName);
+	}
+
 	@Override
 	public Object postProcessBeforeInstantiation(Class<?> beanClass, String beanName) {
 		return null;
diff --git a/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java b/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java
index 51f8886573..060b0ed29e 100644
--- a/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java
+++ b/spring-orm/src/main/java/org/springframework/orm/jpa/support/PersistenceAnnotationBeanPostProcessor.java
@@ -334,6 +334,11 @@ public class PersistenceAnnotationBeanPostProcessor
 		metadata.checkConfigMembers(beanDefinition);
 	}
 
+	@Override
+	public void resetBeanDefinition(String beanName) {
+		this.injectionMetadataCache.remove(beanName);
+	}
+
 	@Override
 	public Object postProcessBeforeInstantiation(Class<?> beanClass, String beanName) {
 		return null;