diff --git a/spring-integration-jdbc/src/main/java/org/springframework/integration/jdbc/lock/JdbcLockRegistry.java b/spring-integration-jdbc/src/main/java/org/springframework/integration/jdbc/lock/JdbcLockRegistry.java
index d5aa450142..1a50141350 100644
--- a/spring-integration-jdbc/src/main/java/org/springframework/integration/jdbc/lock/JdbcLockRegistry.java
+++ b/spring-integration-jdbc/src/main/java/org/springframework/integration/jdbc/lock/JdbcLockRegistry.java
@@ -1,5 +1,5 @@
 /*
- * Copyright 2016-2020 the original author or authors.
+ * Copyright 2016-2021 the original author or authors.
  *
  * Licensed under the Apache License, Version 2.0 (the "License");
  * you may not use this file except in compliance with the License.
@@ -32,6 +32,7 @@ import org.springframework.dao.TransientDataAccessException;
 import org.springframework.integration.support.locks.ExpirableLockRegistry;
 import org.springframework.integration.support.locks.RenewableLockRegistry;
 import org.springframework.integration.util.UUIDConverter;
+import org.springframework.transaction.TransactionSystemException;
 import org.springframework.transaction.TransactionTimedOutException;
 import org.springframework.util.Assert;
 
@@ -52,6 +53,7 @@ import org.springframework.util.Assert;
  * @author Alexandre Strubel
  * @author Stefan Vassilev
  * @author Olivier Hubaut
+ * @author Fran Aranda
  *
  * @since 4.3
  */
@@ -149,7 +151,7 @@ public class JdbcLockRegistry implements ExpirableLockRegistry, RenewableLockReg
 					}
 					break;
 				}
-				catch (TransientDataAccessException | TransactionTimedOutException e) {
+				catch (TransientDataAccessException | TransactionTimedOutException | TransactionSystemException e) {
 					// try again
 				}
 				catch (InterruptedException e) {
@@ -183,7 +185,7 @@ public class JdbcLockRegistry implements ExpirableLockRegistry, RenewableLockReg
 					}
 					break;
 				}
-				catch (TransientDataAccessException | TransactionTimedOutException e) {
+				catch (TransientDataAccessException | TransactionTimedOutException | TransactionSystemException e) {
 					// try again
 				}
 				catch (InterruptedException ie) {
@@ -227,7 +229,7 @@ public class JdbcLockRegistry implements ExpirableLockRegistry, RenewableLockReg
 					}
 					return acquired;
 				}
-				catch (TransientDataAccessException | TransactionTimedOutException e) {
+				catch (TransientDataAccessException | TransactionTimedOutException | TransactionSystemException e) {
 					// try again
 				}
 				catch (Exception e) {
@@ -260,7 +262,7 @@ public class JdbcLockRegistry implements ExpirableLockRegistry, RenewableLockReg
 						this.mutex.delete(this.path);
 						return;
 					}
-					catch (TransientDataAccessException | TransactionTimedOutException e) {
+					catch (TransientDataAccessException | TransactionTimedOutException | TransactionSystemException e) {
 						// try again
 					}
 					catch (Exception e) {
@@ -294,7 +296,7 @@ public class JdbcLockRegistry implements ExpirableLockRegistry, RenewableLockReg
 					}
 					return renewed;
 				}
-				catch (TransientDataAccessException | TransactionTimedOutException e) {
+				catch (TransientDataAccessException | TransactionTimedOutException | TransactionSystemException e) {
 					// try again
 				}
 				catch (Exception e) {
diff --git a/spring-integration-jdbc/src/test/java/org/springframework/integration/jdbc/lock/JdbcLockRegistryDelegateTests.java b/spring-integration-jdbc/src/test/java/org/springframework/integration/jdbc/lock/JdbcLockRegistryDelegateTests.java
index 0efebb97f6..e525d19aa3 100644
--- a/spring-integration-jdbc/src/test/java/org/springframework/integration/jdbc/lock/JdbcLockRegistryDelegateTests.java
+++ b/spring-integration-jdbc/src/test/java/org/springframework/integration/jdbc/lock/JdbcLockRegistryDelegateTests.java
@@ -1,5 +1,5 @@
 /*
- * Copyright 2020 the original author or authors.
+ * Copyright 2020-2021 the original author or authors.
  *
  * Licensed under the Apache License, Version 2.0 (the "License");
  * you may not use this file except in compliance with the License.
@@ -32,10 +32,12 @@ import org.junit.jupiter.api.Test;
 
 import org.springframework.dao.TransientDataAccessException;
 import org.springframework.integration.test.util.TestUtils;
+import org.springframework.transaction.TransactionSystemException;
 import org.springframework.transaction.TransactionTimedOutException;
 
 /**
  * @author Olivier Hubaut
+ * @author Fran Aranda
  *
  * @since 5.2.11
  */
@@ -122,4 +124,22 @@ public class JdbcLockRegistryDelegateTests {
 		assertThat(TestUtils.getPropertyValue(lock, "delegate", ReentrantLock.class).isLocked()).isFalse();
 	}
 
+	@Test
+	public void testTransactionSystemException() {
+		final Lock lock = registry.obtain("foo");
+		lock.tryLock();
+
+		final AtomicBoolean shouldThrow = new AtomicBoolean(true);
+		doAnswer(invocation -> {
+			if (shouldThrow.getAndSet(false)) {
+				throw mock(TransactionSystemException.class);
+			}
+			return null;
+		}).when(repository).delete(anyString());
+
+		lock.unlock();
+
+		assertThat(TestUtils.getPropertyValue(lock, "delegate", ReentrantLock.class).isLocked()).isFalse();
+	}
+
 }