diff --git a/spring-cloud-gateway-server/src/main/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactory.java b/spring-cloud-gateway-server/src/main/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactory.java
index e96e9bc6..97d8c43d 100644
--- a/spring-cloud-gateway-server/src/main/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactory.java
+++ b/spring-cloud-gateway-server/src/main/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactory.java
@@ -17,7 +17,6 @@
 package org.springframework.cloud.gateway.handler.predicate;
 
 import java.util.Arrays;
-import java.util.Collections;
 import java.util.List;
 import java.util.function.Predicate;
 import java.util.regex.Pattern;
@@ -59,9 +58,7 @@ public class HeaderRoutePredicateFactory extends AbstractRoutePredicateFactory<H
 		return new GatewayPredicate() {
 			@Override
 			public boolean test(ServerWebExchange exchange) {
-				List<String> values = exchange.getRequest()
-					.getHeaders()
-					.getOrDefault(config.header, Collections.emptyList());
+				List<String> values = exchange.getRequest().getHeaders().getValuesAsList(config.header);
 				if (values.isEmpty()) {
 					return false;
 				}
diff --git a/spring-cloud-gateway-server/src/test/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactoryTests.java b/spring-cloud-gateway-server/src/test/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactoryTests.java
index 92be2a3a..6792ed97 100644
--- a/spring-cloud-gateway-server/src/test/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactoryTests.java
+++ b/spring-cloud-gateway-server/src/test/java/org/springframework/cloud/gateway/handler/predicate/HeaderRoutePredicateFactoryTests.java
@@ -92,6 +92,20 @@ public class HeaderRoutePredicateFactoryTests extends BaseWebClientTests {
 		assertThat(predicate.toString()).contains("Header: myheader regexp=myregexp");
 	}
 
+	@Test
+	public void headerRouteHandlesCommaSeparatedValues() {
+		testClient.get()
+			.uri("/get")
+			.header("X-Example-Header", "value1, value2 ,exact_match,value3")
+			.exchange()
+			.expectStatus()
+			.isOk()
+			.expectHeader()
+			.valueEquals(HANDLER_MAPPER_HEADER, RoutePredicateHandlerMapping.class.getSimpleName())
+			.expectHeader()
+			.valueEquals(ROUTE_ID_HEADER, "header_test_comma_separated");
+	}
+
 	@EnableAutoConfiguration
 	@SpringBootConfiguration
 	@Import(DefaultTestConfig.class)
@@ -104,6 +118,10 @@ public class HeaderRoutePredicateFactoryTests extends BaseWebClientTests {
 		RouteLocator queryRouteLocator(RouteLocatorBuilder builder) {
 			return builder.routes()
 				.route("header_exists_dsl", r -> r.header("X-Foo").filters(f -> f.prefixPath("/httpbin")).uri(uri))
+				.route("header_test_comma_separated",
+						r -> r.header("X-Example-Header", "exact_match")
+							.filters(f -> f.prefixPath("/httpbin"))
+							.uri(uri))
 				.build();
 		}